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Comparison of the effect of PN-1 inhibition on <t>rotational</t> <t>thromboelastometry</t> parameters between patients with cirrhosis and healthy individuals on platelet-rich plasma. (A) Illustration of the action of PN-1 on fibrinolysis. (B) <t>Rotational</t> <t>thromboelastometry</t> plot in healthy individuals and patients with cirrhosis without and with anti-PN-1 antibody/tPA. Changes in lysis onset time, lysis index at 30 min, lysis index at 45 min, maximum lysis, and lysis time values with anti-PN-1 antibody vs. irrelevant IgG (C) without and (D) with tPA. In the condition without tPA, lysis onset time occurred in five healthy individuals and nine patients with cirrhosis. Comparisons were made using the Mann–Whitney U test. IgG, immunoglobulin g; PN-1, protease nexin 1; tPA, tissue plasminogen activator.
Channel Rotem Delta Device, supplied by Rotem Industries, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rotem%C2%AE+delta/pmc12639314-134-5-6?v=Rotem+Industries
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channel rotem delta device - by Bioz Stars, 2026-08
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rotem delta  (Rotem Industries)
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Rotem Industries rotem delta
Comparison of the effect of PN-1 inhibition on <t>rotational</t> <t>thromboelastometry</t> parameters between patients with cirrhosis and healthy individuals on platelet-rich plasma. (A) Illustration of the action of PN-1 on fibrinolysis. (B) <t>Rotational</t> <t>thromboelastometry</t> plot in healthy individuals and patients with cirrhosis without and with anti-PN-1 antibody/tPA. Changes in lysis onset time, lysis index at 30 min, lysis index at 45 min, maximum lysis, and lysis time values with anti-PN-1 antibody vs. irrelevant IgG (C) without and (D) with tPA. In the condition without tPA, lysis onset time occurred in five healthy individuals and nine patients with cirrhosis. Comparisons were made using the Mann–Whitney U test. IgG, immunoglobulin g; PN-1, protease nexin 1; tPA, tissue plasminogen activator.
Rotem Delta, supplied by Rotem Industries, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rotem%C2%AE+delta/pm41274376-329-2-2?v=Rotem+Industries
Average 86 stars, based on 1 article reviews
rotem delta - by Bioz Stars, 2026-08
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rotem delta device  (Rotem Industries)
86
Rotem Industries rotem delta device
Comparison of the effect of PN-1 inhibition on <t>rotational</t> <t>thromboelastometry</t> parameters between patients with cirrhosis and healthy individuals on platelet-rich plasma. (A) Illustration of the action of PN-1 on fibrinolysis. (B) <t>Rotational</t> <t>thromboelastometry</t> plot in healthy individuals and patients with cirrhosis without and with anti-PN-1 antibody/tPA. Changes in lysis onset time, lysis index at 30 min, lysis index at 45 min, maximum lysis, and lysis time values with anti-PN-1 antibody vs. irrelevant IgG (C) without and (D) with tPA. In the condition without tPA, lysis onset time occurred in five healthy individuals and nine patients with cirrhosis. Comparisons were made using the Mann–Whitney U test. IgG, immunoglobulin g; PN-1, protease nexin 1; tPA, tissue plasminogen activator.
Rotem Delta Device, supplied by Rotem Industries, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rotem%C2%AE+delta/pm41096610-170-7-7?v=Rotem+Industries
Average 86 stars, based on 1 article reviews
rotem delta device - by Bioz Stars, 2026-08
86/100 stars
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rotem delta instrument  (Rotem Industries)
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Rotem Industries rotem delta instrument
Comparison of the effect of PN-1 inhibition on <t>rotational</t> <t>thromboelastometry</t> parameters between patients with cirrhosis and healthy individuals on platelet-rich plasma. (A) Illustration of the action of PN-1 on fibrinolysis. (B) <t>Rotational</t> <t>thromboelastometry</t> plot in healthy individuals and patients with cirrhosis without and with anti-PN-1 antibody/tPA. Changes in lysis onset time, lysis index at 30 min, lysis index at 45 min, maximum lysis, and lysis time values with anti-PN-1 antibody vs. irrelevant IgG (C) without and (D) with tPA. In the condition without tPA, lysis onset time occurred in five healthy individuals and nine patients with cirrhosis. Comparisons were made using the Mann–Whitney U test. IgG, immunoglobulin g; PN-1, protease nexin 1; tPA, tissue plasminogen activator.
Rotem Delta Instrument, supplied by Rotem Industries, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rotem%C2%AE+delta/fda_document____cdrh_docs_slash_reviews_slash_k201440-58-13-13?v=Rotem+Industries
Average 86 stars, based on 1 article reviews
rotem delta instrument - by Bioz Stars, 2026-08
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rotem delta tpa  (Rotem Industries)
86
Rotem Industries rotem delta tpa
Comparison of the effect of PN-1 inhibition on <t>rotational</t> <t>thromboelastometry</t> parameters between patients with cirrhosis and healthy individuals on platelet-rich plasma. (A) Illustration of the action of PN-1 on fibrinolysis. (B) <t>Rotational</t> <t>thromboelastometry</t> plot in healthy individuals and patients with cirrhosis without and with anti-PN-1 antibody/tPA. Changes in lysis onset time, lysis index at 30 min, lysis index at 45 min, maximum lysis, and lysis time values with anti-PN-1 antibody vs. irrelevant IgG (C) without and (D) with tPA. In the condition without tPA, lysis onset time occurred in five healthy individuals and nine patients with cirrhosis. Comparisons were made using the Mann–Whitney U test. IgG, immunoglobulin g; PN-1, protease nexin 1; tPA, tissue plasminogen activator.
Rotem Delta Tpa, supplied by Rotem Industries, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 86 stars, based on 1 article reviews
rotem delta tpa - by Bioz Stars, 2026-08
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Comparison of the effect of PN-1 inhibition on rotational thromboelastometry parameters between patients with cirrhosis and healthy individuals on platelet-rich plasma. (A) Illustration of the action of PN-1 on fibrinolysis. (B) Rotational thromboelastometry plot in healthy individuals and patients with cirrhosis without and with anti-PN-1 antibody/tPA. Changes in lysis onset time, lysis index at 30 min, lysis index at 45 min, maximum lysis, and lysis time values with anti-PN-1 antibody vs. irrelevant IgG (C) without and (D) with tPA. In the condition without tPA, lysis onset time occurred in five healthy individuals and nine patients with cirrhosis. Comparisons were made using the Mann–Whitney U test. IgG, immunoglobulin g; PN-1, protease nexin 1; tPA, tissue plasminogen activator.

Journal: JHEP Reports

Article Title: Platelet protease nexin-1 limits fibrinolysis in patients with cirrhosis ☆

doi: 10.1016/j.jhepr.2025.101563

Figure Lengend Snippet: Comparison of the effect of PN-1 inhibition on rotational thromboelastometry parameters between patients with cirrhosis and healthy individuals on platelet-rich plasma. (A) Illustration of the action of PN-1 on fibrinolysis. (B) Rotational thromboelastometry plot in healthy individuals and patients with cirrhosis without and with anti-PN-1 antibody/tPA. Changes in lysis onset time, lysis index at 30 min, lysis index at 45 min, maximum lysis, and lysis time values with anti-PN-1 antibody vs. irrelevant IgG (C) without and (D) with tPA. In the condition without tPA, lysis onset time occurred in five healthy individuals and nine patients with cirrhosis. Comparisons were made using the Mann–Whitney U test. IgG, immunoglobulin g; PN-1, protease nexin 1; tPA, tissue plasminogen activator.

Article Snippet: ROTEM was conducted using the four-channel ROTEM® Delta device.

Techniques: Comparison, Inhibition, Clinical Proteomics, Lysis, MANN-WHITNEY